Leading practitioners of percutaneous coronary intervention must become experts at recanalizing chronic total occlusions, and with advanced techniques, success rates greater than 90% may be obtained. Moreover, stenting of the unprotected left main coronary artery has emerged as a viable alternative to surgery in selected patients but requires a special skill set and understanding of anatomy, imaging, hemodynamic support, and adjunctive devices. Bringing together leaders in the fields of chronic total occlusions (CTOs) and percutaneous left main intervention, the Complex PCI: Left Main and CTO Summit will be held from the heart of New York City.